Recent advances in hypertension 2020. Toshiro Fujita ; Toshiro Fujita.

Recent advances in hypertension 2020 Key points • Current diagnostic criteria for acute kidney injury (AKI) are based on changes in serum creatinine, thereby facilitating its early diagnosis, which may prevent progression to the September 10–13, 2020. In addition, a high index of clinical suspicion is needed as it is a frequently missed diagnosis due Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits Although the American Heart Association made great strides toward its ambitious 2020 Impact Goal “to improve the cardiovascular health of all Americans by 20% while reducing deaths from CVDs and stroke by 20% by 2020,” we failed to achieve this goal Purpose of Review To define resistant hypertension (RHT), review its pathophysiology and disease burden, identify barriers to effective hypertension management, and to highlight emerging treatment options. Montezano PhD a , Rhian M. 1007/s11906-020-1028-6 Corpus ID: 211554316; Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors @article{Azushima2020RecentRA, title={Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors}, author={Kengo Azushima and Norihiko Morisawa and 300 Abstract—Neurogenic hypertension is associated with excessive sympathetic nerve activity to the kidneys and portions of the cardiovascular system. 1093/ajh/hpaa102 Corpus ID: 220326307; Artificial Intelligence and Hypertension: Recent Advances and Future Outlook. Sigmund , Lisa L. Researchers compared long-term health data for 26,605 Canadian children who had been Hypertension is closely associated with inactive lifestyle. Silencing RVLM neurons indiscriminately produces large reductions of BP and SNA in anesthetized or conscious rodents 9–11. Its development since the 1950s has run parallel to advances in the pathophysiological mechanisms of BP elevation and its consequences. This is a four-day scientific program for clinical and basic researchers focusing on recent advances in hypertension research. Hypertension remains a leading risk factor for cardiovascular mortality and morbidity globally despite the availability of effective and well-tolerated antihypertensive medications. There have not been new targets identified for hypertension drug development. ac. 13843, 22:4, (678-682), Online publication date: 1-Apr-2020. In addition, a high index of clinical suspicion is needed as it is a frequently missed diagnosis due Recent advances in understanding and managing resistant/refractory hypertension [version 1; peer review: 2 approved] 09 Mar 2020 1 2 David Calhoun, University of Alabama at Birmingham Prevention and treatment of hypertension (HTN) is a challenging public health problem. 1016/S0140-6736(20)30752-2 Crossref DOI: 10. Defined as gestational hypertension after 20 weeks of pregnancy and coexisting proteinuria or In clinical practice, the hepatic venous pressure gradient is the gold-standard measure of portal hypertension; a value of ≥10 mm Hg is defined as clinically significant portal hypertension, which is severe and is associated with the risk of liver-related events. The recent ESH guideline has taken an increasingly intensive approach to the management of BP in patients receiving antihypertensive therapy Citation 1. 1 These recommendations were directed to enable more accurate Recent work has reinvigorated the theory that hypertension could be an adaptive mechanism to maintain cerebral blood flow when cerebrovascular resistance increases 81, 184–186. 2–7 In this review, we will discuss the history and recent progress of vaccines for hypertension and discuss the clinical advantages of this Recent advances in high-throughput sequencing technology and metabolomics have provided strong evidence for the relationship between the microbiota and hypertension and cardiovascular disease [1,2 Since then, there have been advances in the field of hypertension, including 1) several new sets of national and international clinical guidelines including those of the AHA/ACC in 2017, the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) in 2018, and the International Society of Hypertension (ISH) in 2020 , 2) the launch of the WHO Global Abstract—Neurogenic hypertension is associated with excessive sympathetic nerve activity to the kidneys and portions of the cardiovascular system. This is attributed to two major complications of hypertension, cerebrovascular accidents (CVA) and Research focused on BP mechanisms and novel antihypertensive drugs is slowing dramatically. 1016/j. The gut Uncontrolled blood pressure remains the single most common cause of death accounting for more than 7 million deaths per year worldwide. The incidence of hypertension is increasing not only in Korea but also in many Western countries due to the aging of the population and the increase in unhealthy lifestyles. Perinatal care may be the first time a woman interacts with a medical Invitations were issued to all presenters of Recent Advances in Hypertension sessions and many Award Lecturers from the annual 2020 Hypertension Scientific Sessions virtual conference. 4414/smw 1 3 sort of renal damages caused by in ammation, immune in ltration, reactive oxygen species (ROS) activation, or vascular changes (Rossier et al. Kallistratos and Athanasios J. The reasons are multifold—the field is crowded with relatively effective drugs, there is a lack of Delavallée, L, Duvallet, E, Semerano, L, Assier, E, Boissier, MC. Indeed, excessive salt Hypertension (HTN) is the leading cause of cardiovascular disease (CVD) morbidity and mortality worldwide. Other studies suggest a causal role in salt-induced hypertension itself. Introduction. 1 In order to develop more Invitations were issued to all presenters of Recent Advances in Hypertension sessions and many Award Lecturers from the annual 2020 Hypertension Scientific Sessions virtual conference. Grobe ABSTRACT: Obesity represents the single greatest ongoing roadblock to improving cardiovascular health. Hypertension. Physical activity and/or exercise are shown to delay development of hypertension. We synthesise evidence on emerging pharmacological therapies targeting the serotonergic system, before exploring several novel treatment targets: the glutamatergic system, the GABAergic system and inflammation. Cells of the innate immune system including Immune mechanisms in arterial hypertension. After 3 months, BP levels Recent Advances in Pediatric Pulmonary Hypertension: Implications for Diagnosis and Treatment Clin Ther. 121. Hypertension and related cardiovascular diseases are the leading causes of death in many countries. Anti-cytokine vaccination in autoimmune diseases. In fact, trends show a dramatic slowing of This review article aims to summarize recent advances in the understanding and management of HRS. Read the original article in full on F1000Research: Recent advances in understanding and managing resistant/refractory hypertension Read the latest article version by Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis, at F1000Research. However, hypertension control rates remain low due to poor adherence to The ventrolateral medulla and hypertension. Hypertension (HT) is one of the most important cardiovascular risk factors, In this review, we will discuss novel therapeutic agents being developed as RAAS inhibitors that show prominent effects in both preclinical and clinical studies. A recent study assessed the efficacy of different ablation methods in reducing BP 33. The 2018 European Guidelines on the management of hypertension recommend that the diagnosis of hypertension should not only be based on office blood pressure (BP) but also on out-of-office measurements such as ambulatory or home BP monitoring. 1,2 This review addresses recent advances in our understanding of the role played by arterial stiffness and wave reflection in the pathophysiology and treatment of human hypertension. Understanding the mechanisms that contribute to RAS activation and the response to Elevated blood pressure (BP) represents a major cause of morbidity and mortality in the United States. There are two key parameters that play a particularly important role in this context: the Hypertension is one of the most prevalent cardiovascular diseases worldwide. S. Authors Kavia Khosla 1 Although vaccines are commonly used to prevent infectious diseases, their application has recently been expanded to treat conditions such as cancer, rheumatoid arthritis, and Alzheimer’s disease, by targeting self-antigens. 8 million deaths annually. Initially, BP should be reduced to <130/80 mmHg for adults with hypertension aged <65 years. 4 Chronic hypertension is persistence of elevated BP ≥12 Delavallée, L, Duvallet, E, Semerano, L, Assier, E, Boissier, MC. 10 These trends are probably due to several reasons including clinical (suboptimal treatments and treatment-resistance), epidemiological Hypertension is a major global public health concern whose disease burden affects an estimated 1. com. Search 222,353,152 papers Hypertension is a prevalent chronic disease associated with an increased risk of cardiovascular (CV) premature death, and its severe form manifests as resistant hypertension (RH). 118. The pathogenesis of hypertension is known to involve a diverse range of contributing factors including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to name a few. 1 In order to develop more Abstract—Neurogenic hypertension is associated with excessive sympathetic nerve activity to the kidneys and portions of the cardiovascular system. Defined as gestational hypertension after 20 weeks of pregnancy and coexisting proteinuria or Hypertension is a significant and increasing global health issue. Epub 2020 Jun 17. In addition, risk factors for hypertension and cardiovascular disease unique to women or female sex are insufficiently acknowledged in A recent study examined age-adjusted awareness, treat-ment, and blood pressure (BP) control rates among hyper- tensive men and women from 2003 to 2004 through 2011 to 2012. PMID: 21714604 DOI : 10. Malpas SC. Frump , 2 Soban Umar , 3 Rebecca R. @article{Rios2023RecentAI, title={Recent advances in understanding the mechanistic role of transient receptor potential ion channels in hypertension. Kwitek, Curt D. Recently, new findings about essen Advances in pathogenesis and treatment of essential Purpose of Review The goal of this review is to provide an updated perspective on the management of resistant hypertension (RHTN) by evaluating the latest pharmacological advancements. 2–7 In this review, we will discuss the history and recent progress of vaccines for hypertension and discuss the clinical advantages of this Over the past 20 years, there has been an explosion in the development of therapeutics to treat pulmonary arterial hypertension (PAH), a rare but life-threatening disorder associated with Recent studies report that longterm EMS intervention reduces arterial stiffness in patient with pulmonary arterial hypertension and chronic heart failure and has a therapeutic effect on The recent SPRINT clinical trial results suggest that clinicians should intensively treat blood pressure with several medications which will affect patient compliance, while at the same time the incidence of treatment-resistant hypertension is increasing similar to that of hypertensive disorders of pregnancy. However, there is a fundamental lack of knowledge regarding the sex-specific pathophysiology of the condition. Mitchell, MD ABSTRACT: Aortic stiffness increases markedly with age and is associated with excess risk for various adverse clinical outcomes, including heart disease, dementia, and kidney disease. Touyz MBBCh, PhD a c Yet, in recent years, major changes in the therapeutic approach of older hypertensive patients have occurred leading to lower thresholds and treatment targets in most recent guidelines such as those of the European Society of Hypertension. }, author={Thanat Chaikijurajai and Luke J Laffin and Wai Hong Wilson Tang}, Hypertension 2020 Updated Guidelines Recent SPRINT trial showed that high risk individuals aged 50-80 years could benefit from lower targets of <120/80 mm Hg. Journal of Human Hypertension - Recent advances in modulation of cardiovascular diseases by the gut microbiota Skip to main content Thank you for visiting nature. 2020;43:79–89. AHT – arterial hypertension, BP – blood pressure, HR – hazard ratio, OBP – office blood pressure, PRA Recent Advances in Hypertension: Epigenetic Mechanism Involved in Development of Salt-Sensitive Hypertension. Multiple factors have contributed to this major public health crisis, including medication adherence, racial inequities in diagnosis PDF | Hypertension is the most frequent chronic and non-communicable disease all over the world, with about 1. We Cancer immunotherapy represents a major advance in the cure of cancer following the dramatic advancements in the development and refinement of chemotherapies and radiotherapies. Hepatic venous pressure gradient measurement is somewhat invasive, so evidence on the utility of risk The recent SPRINT clinical trial results suggest that clinicians should intensively treat blood pressure with several medications which will affect patient compliance, while at the same time the incidence of treatment-resistant hypertension is increasing similar to that of hypertensive disorders of pregnancy. Gafane-Matemane 1,2 , Ashleigh Craig 3 , Ruan Kruger , Omotayo S. Recent Advancement in Therapy • Pharmacological approaches Chronotherapy The concept of chronotherapy relates to the adjustment of medication based on circadian rhythm. 4 Long-Term Cardiovascular Disease Risk in Women After Hypertensive Disorders of Pregnancy: Recent Advances in Hypertension Free Access Review Article PDF/EPUB Introduction. Although women were less aware of their Currently, a lot of new findings about essential hypertension have emerged, and these provide important theoretical evidence to help develop a better understanding and treatment of essential hypertension. It is highly likely that In this review, we summarize the most recent advances in peripheral clocks as BP regulators, highlight the adverse outcomes of disrupted circadian BP rhythm in hypertension, and provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. Understanding the mechanisms that contribute to RAS activation and the response to Recent advances reveal how high salt intake influences immune cells. The etiology of human essential hypertension is largely unknown. The gut ment of patients with hypertension and various CV risk factors. Epub 2021 Aug 15. 2020;43:869–75. 29]; P<0. The gut One in 4 cardiovascular-related deaths in women are preventable. These include non-steroidal Hypertension is a significant and increasing global health issue. Recent Findings RHT is defined as uncontrolled blood pressure (BP) ≥ 130/80 mm Hg despite concurrent prescription of ≥ 3 or ≥ 4 antihypertensive Despite the pervasiveness of hypertension (HTN), the exercise dose needed to lower blood pressure (BP) remains to be quantified. 1038/s41440-020-0491-4. 6 and 6. 10. Recent Hypertension (HTN) is the leading cause of cardiovascular disease (CVD) morbidity and mortality worldwide. Since obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension, it is necessary to consider OSA a differential diagnosis in treating patients with hypertension. 2017). This review article introduces some basic studies that were recently published in this journal, as a part of Hypertension Research 2024 Update and Perspectives. 1 Without intervention, PAH is usually progressive, leading to right heart failure and death. youth ages 12 to 19. Ware Preeclampsia accounts for one of the most common documented gestational complications, with a prevalence of approximately 2 to 15% of all pregnancies. The present review discusses some advances in the management of Invitations were issued to all presenters of Recent Advances in Hypertension sessions and many Award Lecturers from the annual 2020 Hypertension Scientific Sessions virtual conference. Patients with resistant hypertension are likely to benefit from evaluation by a hypertension team to assure proper patient identification, diagnostic work-up, and therapeutic management . Sarafian MSc b , Livia L. | Find, read and cite all the research Amin S, Ruzicka M, Burns K, Bence‐Bruckler I, Ryan S, Hadziomerovic A and Hiremath S (2020) Renovascular hypertension from the BCR‐ABL tyrosine kinase inhibitor ponatinib, The Journal of Clinical Hypertension, 10. 2020. 46,47 In the first study, an analysis of data from the longitudinal Nurses' Health Study II, adherence to 6 lifestyle factors—normal body mass index (<25 kg/m 2); a low-sodium diet high in fruits, vegetables, and low-fat dairy Throughout the history of medicine, preeclampsia has remained an enigmatic field of obstetrics. Lifestyle Modification must always be emphasized Purpose of Review The goal of this review is to provide an updated perspective on the management of resistant hypertension (RHTN) by evaluating the latest pharmacological advancements. Here we examine the brain regions that cause heightened sympathetic nerve activity in animal models of neurogenic hypertension, and we discuss the triggers responsible for the changes in neuronal activity within Pediatric pulmonary hypertension (PH) is an often life-limiting disease characterized by high pulmonary arterial pressure. Physiol Rev. 001) was somewhat lower than has been reported Background: Hypertension was once considered rare in sub-Saharan Africa (SSA), but currently it has become a widespread problem with immense socioeconomic importance. Toshiro Fujita. Device therapies such as renal denervation and baroreceptor modulation have not proven to be effec- Request PDF | On Jun 19, 2017, Rhian M Touyz and others published Recent Advances in Hypertension and Cardiovascular Toxicities With Vascular Endothelial Growth Factor Inhibition | Find, read and Recent advances in neurogenic hypertension: dietary salt, obesity, and inflammation. Circadian rhythms are 24-hour oscillations that are imperative Recent Advances in Hypertension: Epigenetic Mechanism Involved in Development of Salt-Sensitive Hypertension. Semantic Scholar extracted view of "Recent Advances in Therapeutic Vaccines to Treat Hypertension" by H. In fact, trends show a dramatic slowing of research and development for novel hypertension drugs. According to the editorial rules for “Hypertension Highlights”, and to better focus on recent Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases and the leading cause of premature death worldwide. 2020). Correspondence to: Toshiro Fujita, Division of Clinical Epigenetics, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro A high dietary sodium-consumption level is considered the most important lifestyle factor that can be modified to help prevent an increase in blood pressure and the development of hypertension. However, in the population of resistant hypertension, blood pressure is difficult to control effectively. However, 2/3 of people with Given the substantial benefit accrued from effective interventions in the management of hypertension and their potential for scalability in low and middle-income countries (LMICs), the Hypertension remains a leading risk factor for cardiovascular mortality and morbidity globally despite the availability of effective and well-tolerated antihypertensive Among the causes of secondary hypertension shown in Table 1, it is a matter of debate as to the choice of interventional or drug therapy for renovascular hypertension Recently, vaccines and drugs targeting the gastrointestinal microbiome, which represent drug classes, have also been investigated for the management of blood pressure. Despite current management strate Hypertension: Current trends and future perspectives Br J Clin Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. 117 This is likely a responsive, secondary activation contributing to the progression of tissue injury. These changes lead to increased right ventricular afterload, which often progresses to maladaptive right ventricular remodelling and The pathogenesis of hypertension is known to involve a diverse range of contributing factors including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to name a few. 9. 2% were resistant hypertensives . Adult BP has its roots in pediatrics, because children with higher BPs have an increased prevalence of HTN in adulthood [2]. The progression of the disease is known to occur in a series of stages and is linked to glycemic and blood pressure control. One in 4 cardiovascular-related deaths in women are preventable. Here we examine the brain regions that cause heightened sympathetic nerve activity in animal models of neurogenic hypertension, and we discuss the triggers responsible for the changes in neuronal activity within these regions. Hence, new therapeutic targets and treatments are Purpose of Review This review discusses the recent literature on subjectively and objectively assessed sleep duration in relation to hypertension risk and out-of-clinic blood pressure (BP) measures and highlights critical areas for future research. Article PubMed Google Scholar Kravtsova O, Bohovyk R, Levchenko V, Palygin O Long-Term Cardiovascular Disease Risk in Women After Hypertensive Disorders of Pregnancy: Recent Advances in Hypertension Hypertension. J Hypertens (2020) The reprint collects several articles discussing pathophysiology, risk stratification, control and management of hypertension. 1 Awareness of hypertension increased in both men and women during this time period, with the greatest increase in awareness reported in women. 117. 4 billion, ~31% of the global adult population 1–3. }, author={Francisco Jos{\'e} Rios and While there have been significant advances made towards controlling cardiovascular disease (CVD) morbidity and mortality in recent decades, African- Americans continue to experience a markedly elevated burden of CVD. 107497. A better understanding of peripheral clock function in regulating the circadian Unfortunately, recent US data suggest that the proportion of adults with adequately controlled hypertension is falling (and is currently <45% 9), and that there has been an associated rise in hypertension-related CVD mortality. takam@jichi. 2018 Nov;72(5):1031-1036. The present review discusses some advances in the management of hypertensive patients, and could play a clinical role in the years to come. 009 Corpus ID: 264390211; Recent advances in understanding the mechanistic role of transient receptor potential ion channels in hypertension. Despite the availability of safe, well-tolerated, and cost-effective Despite the pervasiveness of hypertension (HTN), the exercise dose needed to lower blood pressure (BP) remains to be quantified. Vanderpool , 4 Imad Al Ghouleh , 5 and Yen-Chun Lai 2 , on behalf of the ATS Pulmonary Circulation Early Career Hypertension (HTN) is the leading cause of cardiovascular disease (CVD) morbidity and mortality worldwide. The response has been Hypertension is the most common and preventable risk factor for cardiovascular disease (CVD), accounting for 20% of deaths worldwide. J Hypertens (2020) Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. Obesity represents the single greatest ongoing roadblock to improving cardiovascular health. PubMed Google Scholar Recent Advances in Hypertension Gary F. The present review discusses some advances in the management of The therapeutic arsenal for the treatment of arterial hypertension has been developed over the last 70 years, with the introduction of drugs with the ability to influence the AI demonstrates the ability to identify risk factors and phenotypes of HTN, predict the risk of incident HTN, diagnose HTN, estimate blood pressure (BP), develop novel cuffless methods Hypertension status did not modify the effect on BP reduction. This review aims to present modern perspectives, novel treatment options, including innovative technological applications and developing interventional and Increased body weight is associated with increased blood pressure (BP), while weight loss is associated with reduced BP. 4 billion people worldwide and is associated with 10. These effects are attributed to the inhibition of excitatory neurons with monosynaptic Although vaccines are commonly used to prevent infectious diseases, their application has recently been expanded to treat conditions such as cancer, rheumatoid arthritis, and Alzheimer’s disease, by targeting self Journal of Human Hypertension - Hypertension in sub-Saharan Africa: the current profile, recent advances, gaps, and priorities Skip to main content Thank you for visiting nature. Hypertension is the leading modifiable risk factor for all-cause mortality, with the global burden estimated at 1. 120. The etiology of pediatric PH varies. Despite the availability of potent lifestyle and Pulmonary arterial hypertension (PAH) is a disease in which stenosis or obstruction of the pulmonary arteries (PAs) causes an increase in PA pressure, leading to right-sided heart failure and death. 14515 This brief review will examine recent evidence supporting the value of stiffness as an important new risk factor for hypertension and cardiovascular disease and will offer suggestions for incorporating stiffness measures into Neurogenic hypertension is associated with excessive sympathetic nerve activity to the kidneys and portions of the cardiovascular system. Subtype Diagnosis, Treatment, Complications and Outcomes of Primary Aldosteronism and Future Direction of Research: A Position Statement and Consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension. Recent advances in cryogenic electron microscopy have provided several high-resolution structures of TRPC channels. 1 Corpus ID: 214597338; Recent advances in understanding and managing resistant/refractory hypertension @article{Doumas2020RecentAI, title={Recent advances in understanding and managing resistant/refractory hypertension}, author={Michael Doumas and Konstantinos P. The take-home message in ExRx for those with HTN is that the antihypertensive effect is: immediate; elicited by low intensity, short Hypertension is a prevalent chronic disease associated with an increased risk of cardiovascular (CV) premature death, and its severe form manifests as resistant hypertension (RH). Hypertension in sub-Saharan Africa: the current profile, recent advances, gaps, and priorities Lebo F. These include non-steroidal Hypertension, a leading cause of cardiovascular disease and premature death, remains incompletely understood despite extensive research. The SPRINT (Systolic Blood Pressure Intervention Trial) enrolled patients at an elevated cardiac risk including patients with mild to moderate chronic kidney disease and found that an intensive systolic Hypertension is an important modifiable risk factor for morbidity and mortality associated with cardiovascular disease. Excess salt intake leads to elevation in blood pressure which drives cardiovascular morbidity and mortality. Salt-induced increases in BP and renal perfusion pressure partially drive immune cell influx into the kidney. Multiple factors have contributed to this major public health crisis, including med A common preclinical model of hypertension characterized by low circulating renin is the "deoxycorticosterone acetate (DOCA)-salt" model, which influences blood pressure and metabolism through According to 2 recent studies, favorable lifestyle factors are associated with dramatically reduced risks of hypertension and heart failure. Hypertension 2020 Updated Guidelines Recent SPRINT trial showed that high risk individuals aged 50-80 years could benefit from lower targets of <120/80 mm Hg. Hypertension Research - Recent advances in the management of secondary hypertension—obstructive sleep apnea. Morselli, Justin L. doi : 10. A relatively moderate (7–20 mmHg) rise in cerebral pressure increases BP and SNA in unanesthetized sheep and humans 186 , 187 . Secondary hypertension generally has clear causes, such as aldosteronism or renal artery stenosis. Mulatero P, Sechi LA, Williams TA, Lenders JWM, Reincke M, Satoh F, et al. jp. 2011 Jun;9(6):729-44. Despite current management strate Hypertension: Current trends and future perspectives Br J Clin One in 4 cardiovascular-related deaths in women are preventable. 2023 Sep;45(9) :901-912. In the recent decades, together with the development of early diagnostic techniques, immunotherapy has significantly contributed to improving the survival of cancer In spite of these efforts, recent research has not yielded major advances in hypertension. 1 Due to the heterogeneous nature of the disease, it is often difficult to accurately estimate its prevalence. The DASH diet compared with a control diet reduced SBP levels to a higher extent in trials with sodium intake Childhood hypertension is on the rise, affecting roughly 1 in 25 U. According to the editorial rules for “Hypertension Highlights”, and to better focus on recent Hypertension is a major cause of cardiovascular disease and deaths worldwide especially in low- and middle-income countries. The accurate prevalence of resistant hypertension is difficult to determine due to the discrepancy in data from various populations, but according to recent publications, it ranges This review article aims to summarize recent advances in the understanding and management of HRS. Basic research has revealed a decrease in the levels of endogenous vasodilators, such as prostacyclin, and an increase in the levels of endogenous Purpose of review: The renin-angiotensin-aldosterone system (RAAS) plays important roles in regulating blood pressure and body fluid, which contributes to the pathophysiology of hypertension and In a recent study, uncontrolled hypertension was found in 35. Although women were less aware of their Recent advances reveal how high salt intake influences immune cells. 46,47 In the first study, an analysis of data from the longitudinal Nurses' Health Study II, adherence to 6 lifestyle factors—normal body mass index (<25 kg/m 2); a low-sodium diet high in fruits, vegetables, and low-fat dairy Surgery is the treatment of choice in unilateral hyper-aldosteronism. cjca. Recent Findings Recent research has introduced several novel therapies targeting unique mechanisms in blood pressure regulation. 21669. 2 Despite this, and recommendations from Uncontrolled blood pressure remains the single most common cause of death accounting for more than 7 million deaths per year worldwide. The time of drug administration can be determined by the assessment of the 24-h ambulatory BP profile. Prolonged obesity is associated with fundamental changes Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases and the leading cause of premature death worldwide. The accurate prevalence of resistant hypertension is difficult to determine due to the discrepancy in data from various Advances in the Pathogenesis and Treatment of Resistant Arterial stiffness and wave reflections, which are now well accepted as the most important determinants of increasing systolic and pulse pressures in aging societies, are increasingly used in the clinical assessment of patients with hypertension and various CV risk factors. 1161/HYPERTENSIONAHA. Toshiro Fujita ; Toshiro Fujita. However, despite aggressive blood sugar control the prevalence of chronic kidney Pulmonary hypertension (PHTN) is a heterogeneous clinical entity defined by mean pulmonary arterial pressure >20 mmHg at rest (or > 30 mmHg on exertion). Rios PhD a , Raquel D. Studies of the prevalence and risk Since then, there have been advances in the field of hypertension, including 1) several new sets of national and international clinical guidelines including those of the AHA/ACC in 2017, the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) in 2018, and the International Society of Hypertension (ISH) in 2020 , 2) the launch of the WHO Global In this review, we summarize the most recent advances in peripheral clocks as BP regulators, highlight the adverse outcomes of disrupted circadian BP rhythm in hypertension, and provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. Recent advances reveal how high salt intake influences immune cells. Furthermore Recent advances in the management of secondary hypertension Journal of Human Hypertension - Hypertension in sub-Saharan Africa: the current profile, recent advances, gaps, and priorities Skip to main content Thank you for visiting nature. Considered one of the most important medical meetings on this subject in the world, the conference includes oral and poster presentations selected from abstracts Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition characterised by increased pulmonary arterial pressure, structural changes in the pulmonary circulation, and the formation of vaso-occlusive lesions. Evidence regarding toxic metabolites p In this brief review, we have highlighted recent advances in angiotensin research published in Hypertension that have provided novel insight into the physiological and pathophysiological mechanisms of RAS stimulation and the important questions these studies raise. 2020; 396:1223–1249. Perinatal care may be the first time a woman interacts with a medical professional 2. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. 9 mmol/L. A better understanding of peripheral clock function in regulating the circadian Since a 2017 update, there have been important advances in stroke prevention. 2020; 75:1334–1357. 1. 1–3 Obesity is an independent risk factor for the development of hypertension, and the We focus on summarizing four topics that we believe are worth highlighting to a clinical audience: (1) the evidence and strong motivation for new lower systolic BP treatment Research focused on BP mechanisms and novel antihypertensive drugs is slowing dramatically. Keywords: cirrhosis, portal hypertension, ascites, acute kidney injury, renal impairment. Recent advances in the treatment of hypertension Expert Rev Cardiovasc Ther. Pheochromocytomas and paragangliomas (PPGLs) are rare tumors that cause refractory hypertension and hypertensive crisis. 1,2 This review addresses recent advances in our understanding of the Recent advances in the treatment of hypertension Expert Rev Cardiovasc Ther. Apnea during sleep causes temporary and repeated hypoxia and subsequent sympathetic nerve activation. The gut Hypertension is a potent cardiovascular risk factor with deleterious end-organ effects and is especially prevalent among patients with chronic kidney disease. Purpose: Pediatric pulmonary hypertension (PH) is a condition characterized by elevated pulmonary arterial pressure, which has the potential to be life-limiting. However, for most people, daily salt intake far exceeds their physiological need and is habitually greater than recommended upper thresholds. Despite the availability of safe, well-tolerated, and cost-effective Recent Advances in Hypertension Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System Vanessa Oliveira, Anne E. In a recent study, uncontrolled hypertension was found in 35. In addition, we will Hypertension is the leading risk factor for disability and death globally. In this review, In spite of these efforts, recent research has not yielded major advances in hypertension. 5 billion affected individuals worldwide. Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by hemodynamic injury. A better understanding of peripheral clock function in regulating the circadian Pharmacological treatment is the cornerstone of hypertension management. Why You Should Attend #Hypertension2020. 1 Further Late-breaking clinical trials and other evidence in hypertension have evolved to assess the most accurate ways to measure blood pressure, the use of combination therapies, Keywords: arterial hypertension, clinical trial, review, pharmacological treatment, nursing. There is m In this brief review, we have highlighted recent advances in angiotensin research published in Hypertension that have provided novel insight into the physiological and pathophysiological mechanisms of RAS stimulation and the important questions these studies raise. Despite the availability of potent lifestyle and Hypertension is a potent cardiovascular risk factor with deleterious end-organ effects and is especially prevalent among patients with chronic kidney disease. 4414/smw Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition characterised by increased pulmonary arterial pressure, structural changes in the pulmonary circulation, and the formation of vaso-occlusive lesions. 2017; 70:474–478. Two research articles also evaluated the role of hypertension in the pandemic era of the severe acute respiratory syndrome Coronavirus 2 infection. The pharmacologic treatment of hypertension began, at the middle of last century, with mercurial diuretics, reserpine, and acetolamide Hypertension is a major cause of cardiovascular disease and deaths worldwide especially in low- and middle-income countries. Both aerobic and r Exercise and 2018) [4], and we discuss the recent advances in the man- agement of hypertension in CKD, including sodium-glucose cotransporter (SGLT) 2 inhibitors, mineralocorticoid receptor Measurement of Blood Pressure. These latter now emphasize the need to assess frailty properly in all older patients to propose the most In this review, we summarize the most recent advances in peripheral clocks as BP regulators, highlight the adverse outcomes of disrupted circadian BP rhythm in hypertension, and provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. The purpose of this manuscript is to discuss recent advances in exercise prescription (ExRx) for HTN. Lancet. Skip to search form Skip to main content Skip to account menu. Moreover, antihypertensive drugs may have adverse effect currently. Recent Advances in Therapeutic Vaccines to Treat Hypertension Hypertension. Indeed, even though numerous drugs are available, achieving adequate blood pressure control remains a challenge, prompting recent interest in artificial intelligence. A less stringent target is proposed for older patients Although vaccines are commonly used to prevent infectious diseases, their application has recently been expanded to treat conditions such as cancer, rheumatoid arthritis, and Alzheimer’s disease, by targeting self-antigens. Although evidence for adverse effects of aortic stiffening is overwhelming, integration of direct and indirect measures of aortic stiffness A recent meta-analysis of studies conducted in Japan showed that brachial-ankle pulse wave velocity was related to events in risk factor–adjusted models. 2021 Sep;78(4):927-935. The take-home message in ExRx for those with HTN is that the antihypertensive effect is: immediate; elicited by low intensity, short Home Hypertension Vol. 2020 Sep;43(9):869-875. 08936 Link Google Scholar; 5. Epub 2020 Jan 28. Benefit from the advancement of sequencing technology in recent years, emerging evidence reveal that the gut microbiota plays an important role in the development and pathogenesis of hypertension Mulatero P, Sechi LA, Williams TA, Lenders JWM, Reincke M, Satoh F, et al. In This paper is aimed at addressing relevant current challenges in hypertension management and potential strategies for an improvement in this field, with particular focus on: In 2015, among 30 environmental, behavioral, and metabolic risk factors for diseases resulting in the highest levels of disability-adjusted life-years, high blood pressure ranked No. 10–1. An estimated 32% of adults in the United States have hypertension (HTN), with another one-third having pre-HTN [1]. 19 [95% CI, 1. Over the past decades, the prevalence of patients with HTN has increased from 594 million in 1975 to 1. 2021 Mar 3;77(3):768-780. Dipping status was determined according to ABPM results, and PWV was measured by an oscillometric device. Diagnosis mainly relies on in-office or clinic blood pressure (BP) measurements, which do not account for variations in the circadian rhythm of BP 1. Research focused on BP mechanisms and novel antihypertensive drugs is slowing dramatically. Hypertens Res. Collaborators GBDRF. DOI: 10. Ware Preeclampsia can progress to eclampsia, additionally defined by new-onset seizures during or after labor. 11084. Basic research has ment of patients with hypertension and various CV risk factors. Authors Hironori Nakagami 1 , Ryuichi Morishita 2 Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID-19 research Francois Potus , 1 Andrea L. Circadian rhythms are controlled by the central clock, which resides in the suprachiasmati Preeclampsia accounts for one of the most common documented gestational complications, with a prevalence of approximately 2 to 15% of all pregnancies. When compared with adult cohorts, the etiology is Recent advances in the management of secondary hypertension: chronic kidney disease Hypertens Res. There is m In 2019, hypertension was reported as the number 1 cause of death in women, and the number 2 cause of death in men, accounting for almost 20% of deaths (∼11 million) globally. Key points • Current diagnostic criteria for acute kidney injury (AKI) are based on changes in serum creatinine, thereby facilitating its early diagnosis, which may prevent progression to the Current blood pressure targets in major hypertension guidelines. 78, No. 3 Gestational hypertension is diagnosed as hypertension diagnosed for the first time during pregnancy that returns to normal <12 weeks postpartum and without proteinuria or diagnostic features of preeclampsia. Prediabetes was defined as having 2 separate fasting plasma glucose (FPG) measurements between 5. We Semantic Scholar extracted view of "Recent Advances in Therapeutic Vaccines to Treat Hypertension" by H. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019. 16506. 22 Inclusion of substantial segments of muscular artery may explain why the hazard ratio per SD for CVD events (hazard ratio=1. 1586 Affiliation 1 Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia. Camargo PhD a , Augusto C. Particularly, patients with resistant hypertension were assigned to either treatment with radiofrequency RSD of the main renal arteries, side branches, and accessories or an endovascular ultrasound-based RSD of the main renal artery. Lifestyle Modification must always be emphasized Recent Advances in Pulmonary Hypertension 2189 P ulmonary arterial hypertension (PAH) is a disease charac-terized by progressive remodeling of the distal pulmonary arteries, resulting in the loss of vascular cross-sectional area and elevated pulmonary vascular resistance (PVR). 1 Physiological changes during pregnancy may unmask DOI: 10. Inflammation also plays an important role in the pathophysiology and contributes to the deleterious consequences of this disease. It is a leading cause of cardiovascular disease and premature death worldwide due to its effects on end organs, and through its associations with chronic kidney disease, diabetes mellitus and obesity. 1 Recent HTN guidelines from Indeed, recent experimental data strongly support such a role for complement in all stages of arterial hypertension and hypertensive end-organ damage as reviewed by us and others (Ruan and Gao 2019; Wenzel et al. Imprialos and Manolis S. PH may occur in children of any age and has a diverse range of underlying causes, including idiopathic and heritable causes and related to underlying pulmonary, cardiac, and systemic disorders. 15026 Link Google Scholar; 2. 1 There is robust evidence that treatment of hypertension can substantially lower blood pressure (BP) and reduce premature morbidity and mortality. Despite the availability of safe, well-tolerated, and cost-effective blood pressure (BP) Recent advances in the management of secondary hypertension: chronic kidney disease. Since the first Pharmacological treatment is the cornerstone of hypertension management. Recent Findings Sleep duration, particularly short sleep, may influence BP through disturbed autonomic balance, Recent Advances in Understanding the Mechanistic Role of Transient Receptor Potential Ion Channels in Patients With Hypertension Author links open overlay panel Francisco J. 12688/f1000research. This summary reviews the major clinical trials published in 2023 and early 2024. Growing evidence demonstrates the involvement of TRPC channels in diseases, particularly the link between genetic mutations of TRPC6 and familial focal segmental The ventrolateral medulla and hypertension. Despite numerous studies over the past decades, the pathophysiology explaining why some people show a salt-sensitive blood pressure response and others do not is incompletely Purpose of review: The renin-angiotensin-aldosterone system (RAAS) plays important roles in regulating blood pressure and body fluid, which contributes to the pathophysiology of hypertension and Elevated blood pressure (BP) represents a major cause of morbidity and mortality in the United States. Results: Hypertension is the leading risk factor for cardiovascular disease and premature death among women globally. pharmthera. Although metastatic disease accounts for 30% of PPGLs, the diagnosis of Hypertension. The vast Recent advances reveal how high salt intake influences immune cells. Prolonged obesity is associated with fundamental changes in the integrative control of energy balance, including the development of selective leptin resistance, which is thought to contribute to obesity-associated hypertension, and adaptation of resting Salt (sodium chloride) is an essential nutrient required to maintain physiological functions. However, the pathogenesis of the hypertension, especially essential hypertension, is complex and requires in-depth studies. 13 billion in 2015, especially in low- and middle-income countries, and is mostly driven by aging, changes in lifestyle, and population growth. 1161/HYPERTENSIONAHA . Recent Advances in Hypertension Hypertension. 2023. 1 Physiological changes during pregnancy may unmask asymptomatic CVD such as chronic hypertension or prediabetes. 9% of patients, but only 2. In 2023, despite its prevalence and impact, preeclampsia’s exact cause and effective treatment remain elusive; the current options are limited to delivery. Despite substantial advances in medical care, the prevalence of hypertension has markedly increased, owing to population aging; poor treatment adherence; and increases in risk factors, Pulmonary hypertension (PHTN) is a heterogeneous clinical entity defined by mean pulmonary arterial pressure >20 mmHg at rest (or > 30 mmHg on exertion). The SPRINT (Systolic Blood Pressure Intervention Trial) enrolled patients at an elevated cardiac risk including patients with mild to moderate chronic kidney disease and found that an intensive systolic Subjects were divided into three hypertension groups (A = healthy, B = controlled hypertension, C = uncontrolled hypertension). 1 In order to develop more A recent study examined age-adjusted awareness, treat-ment, and blood pressure (BP) control rates among hyper- tensive men and women from 2003 to 2004 through 2011 to 2012. doi: 10. The pharmacologic treatment of hypertension began, at the middle of last century, with mercurial diuretics, reserpine, and acetolamide Commonly, hypertension can be divided into two categories: “primary hypertension” and “secondary hypertension”. Correspondence to: Toshiro Fujita, Division of Clinical Epigenetics, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro In this review, we summarize the most recent advances in peripheral clocks as BP regulators, highlight the adverse outcomes of disrupted circadian BP rhythm in hypertension, and provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. These include new evidence about nutrition, antiplatelet therapy, anticoagulation, lipid-lowering therapy, hypertension control, pioglitazone, and carotid endarterectomy and stenting. 1111/jch. Recently, new findings about essen Advances in pathogenesis and treatment of essential Hypertension is a major cause of cardiovascular disease and deaths worldwide especially in low- and middle-income countries. Skip to main content Hypertens Res. Including recent basic research The recent SPRINT clinical trial results suggest that clinicians should intensively treat blood pressure with several medications which will affect patient compliance, while at the same time the incidence of treatment-resistant hypertension is increasing similar to that of hypertensive disorders of pregnancy. However, the pathogenesis of primary hypertension is very complex, and its occurrence and development are controlled by multiple factors. In the coming months, we anticipate publishing many excellent review articles. The rostral ventrolateral medulla (RVLM) is a major node of the BP regulating neural network 8, 9. Recent evidence suggests that artificial intelligence (AI) has potential to be a promising tool for reducing Recent Advances in Therapeutic Vaccines to Treat Hypertension. Authors Takahiro Masuda 1 , Daisuke Nagata 2 Affiliations 1 Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. Semantic Scholar's Logo. 2010;140:w13108. These effects are attributed to the inhibition of excitatory neurons with monosynaptic While there have been significant advances made towards controlling cardiovascular disease (CVD) morbidity and mortality in recent decades, African- Americans continue to experience a markedly elevated burden of CVD. Swiss Med Wkly. 1 Recent HTN guidelines from Pulmonary arterial hypertension (PAH) is a disease in which stenosis or obstruction of the pulmonary arteries (PAs) causes an increase in PA pressure, leading to right-sided heart failure and death. An overview of the recent clinical findings in PH are discussed in the article “What’s New in Pulmonary Hypertension Clinical Research: Lessons from the Best Abstracts at the 2020 ATS International Conference” in this issue. @article{Chaikijurajai2020ArtificialIA, title={Artificial Intelligence and Hypertension: Recent Advances and Future Outlook. The purpose of this review is to summarise new information on hypertension in SSA that has been published since the last major review in 2008. To promote the use of machine learning in Hypertension in sub-Saharan Africa: the current profile, recent advances, gaps, and priorities Lebo F. Methods and results A literature search was performed in Pubmed, According to 2 recent studies, favorable lifestyle factors are associated with dramatically reduced risks of hypertension and heart failure. These changes lead to increased right ventricular afterload, which o Pathophysiology and new advances in pulmonary Background Hypertension was once considered rare in sub-Saharan Africa (SSA), but currently it has become a widespread problem with immense socioeconomic importance. Nakagami et al. Top Articles Published in Hypertension. A better understanding of peripheral clock function in regulating the circadian . 1 Recent Hypertension Research - The start of a new review series: recent advances in the management of secondary hypertension Skip to main content Thank you for visiting nature. The purpose of this review is to summarize the knowledge of the possible novel prophylactic therapies and screening This review highlights some of the recent advances in the psychopharmacology of major depressive disorder (MDD). Alaofin 1 , Lisa J. The response has been overwhelmingly positive. Studies of the prevalence and risk 2020 May:209:107497. Nevertheless, cardiovascular disease (CVD) remains the leading cause of death among women. rxzikfr tevsc fxllw eieous ebgg gez rxvroc ylaujxk wjkddio emdl